If A is brother of B. B is the sister of C and C is the father of D, then how is D related to A?
If A is brother of B. B is the sister of C and C is the father of D, then how is D related to A?
A, B and C are siblings (A is B's brother, B is C's sister). Since C is D's father, D is the child of A's sibling, making D the nephew/niece of A.
Re-check your working by substituting the answer back into the original question.